抗癌药的治疗指数通常很窄,产生急性毒性反应和治疗效果的剂量往往很接近。严重的毒性反应,如粒细胞减少症、血小板减少症可能危及生命,而剂量不足的后果也将危及病人生命。对药物敏感的癌瘤,避免化疗剂量过低是很重要的,因此有必要采用更为精确的方法来确定病人个体的最大耐受剂量。几个临床试验已证实了抗癌药物的剂量-反应相互关系,从而促进了对药动学曲线和治 Therapeutic indices of anticancer drugs are usually very narrow, and doses that produce acute toxicities and therapeutic effects are often very close. Serious toxic reactions, such as neutropenia, thrombocytopenia may be life-threatening, and the consequences of under-dosing will endanger the life of the patient. For drug-sensitive cancers, it is important to avoid overdosage of chemotherapy and it is therefore necessary to use a more accurate method to determine the maximum tolerated dose of a patient. Several clinical trials have confirmed the dose-response relationship of anti-cancer drugs, thereby promoting pharmacokinetic curves and treatment