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目的探讨去乙酰化酶6在胃癌中的表达及其临床意义。方法选取作者医院2011-10/2013-10月收治的胃癌患者87例为观察组,选取本院同期胃黏膜慢性炎症患者83例为对照组,采用免疫组织化学和原位杂交法检测去乙酰化酶6蛋白和mRNA的表达,分析胃癌患者病理组织的分化程度、浸润深度、淋巴结转移与乙酰化酶6蛋白和mRNA表达的关系,分析胃癌患者乙酰化酶6蛋白与mRNA的相关性。结果观察组患者乙酰化酶6蛋白阳性率、乙酰化酶6 mRNA阳性率均明显高于对照组。乙酰化酶6蛋白、乙酰化酶6 mRNA与病理组织分化程度、病理组织浸润深度、淋巴结转移均具有明显的正相关性。结论乙酰化酶6蛋白和mRNA表达有助于判定胃癌患者的临床病症和生物学行为,具有高度的临床意义。
Objective To investigate the expression of sirtuin-6 in gastric cancer and its clinical significance. Methods Eighty-seven patients with gastric cancer admitted to our hospital from October 2011 to October 2013 were selected as the observation group. Totally 83 patients with chronic inflammation of gastric mucosa in our hospital were selected as control group. Deacetylation was detected by immunohistochemistry and in situ hybridization The relationship between the expression of acetylated 6 protein and mRNA and the histopathological differentiation, invasion depth, lymph node metastasis and the expression of acetylase 6 protein in gastric cancer patients were analyzed. Results The positive rate of acetylase 6 and the positive rate of acetylase 6 mRNA in observation group were significantly higher than those in control group. The expressions of acetylated 6 and acetylated 6 mRNA were positively correlated with the degree of pathological differentiation, the depth of pathological invasion and lymph node metastasis. Conclusions The expression of acetylase 6 protein and mRNA may be helpful in judging the clinical symptoms and biological behavior of patients with gastric cancer. It is of high clinical significance.