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驱虫净常见副作用为腹痛、头昏等.现报告两例由于服用过量所致急性谵妄状态如下:例1,陈×,男,10岁.81年4月20日晚服驱虫净150mg,凌晨又服150mg,驱抠出蛔虫约50条.中午出现恶心,烦躁不安、拒食、幻视等症状.下午就诊,检查:心肺、腹部(-),意识模糊,偶有恐惧性尖叫,腱反射活跃、双侧霍夫曼、屈指、掌颏反射阳性.实验室及ECG,EEG均未见异常.诊断艺语性谵妄(驱虫净过量).治疗:经奋乃静4mg一日三次,并给输液及一般支持疗法,三天后恢复正常.例2 周×,女,13岁.83年4月23日三次共服驱虫净450mg, 当晚出现腹痛,头昏,情绪不稳,幻视.次晨排出蛔虫87条.下午因严重精神失常来院就诊.检查;腱反射活跃、霍夫曼、屈指反射阳性.意识模糊,时间、地点、人物走向困难,兴奋乱沈,心电图、血常规、脑脊液常规生化都无病理改变.诊断药物往谵妄(驱虫净过量).入院后经氯丙嗪、泰而登,奋乃静、五氟利多等抗精神病药物治疗一周后谵妄状态控制,出现忧郁症状悲观焦虑,四肢震颤、肌肉僵硬、静坐不绝,流涎,大汗及轻生之念.后停用所有抗精神病药物,给氢溴酸东莨菪碱0.3mg肌注一日三次,安坦2mg一日三次口服,并给输液等支持治疗.住院三周痊愈出院.
Common side effects of deworming net abdominal pain, dizziness, etc. It is reported that two cases due to overdose caused by acute delirium state as follows: Example 1, Chen ×, male, 10 years old. April 20, 81 evening deworming net 150mg, In the early morning and served 150mg, drive dig roundworm about 50. Noon appeared nausea, irritability, antifeedant, visual hallucinations and other symptoms. Afternoon treatment, check: heart and lungs, abdomen (-), confusion, occasional fear scream, tendon Reflex active, bilateral Huffman, flexor finger, palm chin reflex positive.Laboratory and ECG, EEG were no abnormalities .Study of Art language delirium (deworming net excess.) Treatment: Perphenazine 4mg three times a day, And give infusion and general supportive therapy, returned to normal after three days .Example 2 weeks ×, female, 13 years old. April 23, 83 three times a total of 450 ml decontamination, evening abdominal pain, dizziness, emotional instability, hallucination .The next morning the discharge of roundworm 87. In the afternoon due to severe mental disorders to the hospital for treatment.Check; tendon reflexes active, Huffman, flexor reflex positive.Convergence of confusion, time and place, the characters to difficulties, excited chaos Shen, ECG, blood, Cerebrospinal fluid routine biochemical pathology no change to diagnostic drugs to delirium (deworming net excess.) After admission by chlorpromazine, Thai and Deng, Is static, pentafluoridone and other antipsychotic treatment after a week of delirium state control, depression and anxiety symptoms appear pessimistic tremor, muscle stiffness, sedentary, salivation, sweating and abstinence after the withdrawal of all antipsychotics, To scopolamine hydrobromide 0.3mg intramuscularly three times a day, 2mg AnTan three times a day orally, and infusion and other supportive treatment. Hospitalized three weeks discharged.