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目的:观察肾炎康复片联合舒洛地特治疗早期慢性肾脏病(CKD)的效果。方法:88例早期慢性肾脏病患者随机分为2组,对照组给予低盐低脂低蛋白饮食,常规基础治疗(ACEI或ARB)、控制血糖、对症等治疗,观察组在对照组基础上加服肾炎康复片2.4 g,po,tid,舒洛地特250 LSU/次,bid,疗程4个月,每2个月监测24h尿蛋白定量、尿红细胞(URBC)、尿白蛋白排泄率、尿N-乙酰-β-D-葡萄糖苷酶(NAG)、C-反应蛋白(CRP),β_2-微球蛋白(β_2-MG)、肾小球滤过率(GFR)、肝功、血脂、血糖等指标。结果:2组治疗4个月后24 h尿蛋白定量、URBC、尿白蛋白排泄率、NAG、CRP、β_2-MG和GFR等指标均较治疗前明显好转(P<0.05或P<0.01),且观察组上述指标均明显优于对照组(P<0.05)。结论:肾炎康复片联合舒洛地特能延缓早期CKD的进展。
Objective: To observe the effect of nephritis and konjac combined with sulodentia in the treatment of early chronic kidney disease (CKD). Methods: Eighty-eight patients with early-stage chronic kidney disease were randomly divided into two groups. The control group was given low-salt, low-fat and low-protein diet, routine basic treatment (ACEI or ARB), blood glucose control and symptomatic treatment. Nephritis rehabilitation tablets 2.4 g, po, tid, sulodexide 250 LSU / time, bid, treatment for 4 months, every 24 months to monitor urinary protein, urinary red blood cells (URBC), urinary albumin excretion rate, urine Β-D-glucosidase (NAG), C-reactive protein (CRP), β_2-microglobulin (β_2-MG), glomerular filtration rate (GFR), liver function, And other indicators. Results: Urine protein, URBC, urinary albumin excretion rate, NAG, CRP, β_2-MG and GFR in 24 hours after treatment in both groups were significantly improved (P <0.05 or P <0.01) The above indexes in the observation group were significantly better than those in the control group (P <0.05). Conclusion: Shenyinkang tablets combined with sulodexide can delay the progression of early CKD.