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目的循证探讨1例慢性阻塞性肺疾病(COPD)患者使用沙美特罗是否有效。方法针对COPD患者使用沙美特罗吸入治疗是否有效的问题,计算机检索EMbase网站(2007～2011),EBSCOhost网站(2000～2010),获取并评价相关系统评价、Meta分析和随机对照试验,并将最佳证据用于临床实践。结果初检到系统评价2篇、Meta分析3篇、随机对照试验172篇,经过筛选,最终纳入RCT 12篇,Meta分析1篇。结果提示,吸入沙美特罗后COPD患者的肺功能有明显改善,临床症状得到缓解及生活质量有所提高。将以上证据结合患者意愿应用于该名患者后效果良好。结论对COPD患者给予沙美特罗吸入治疗能明显改善患者肺功能,缓解临床症状和提高生活质量。但因其仍存在一些不良反应,在实际应用中应该综合考虑。
Objective To investigate the feasibility of using salmeterol in one patient with chronic obstructive pulmonary disease (COPD). Methods To investigate the effectiveness of salmeterol inhalation in patients with COPD, we searched the EMbase website (2007 ~ 2011) and EBSCOhost website (2000 ~ 2010), and obtained and evaluated the relevant systematic reviews, meta-analysis and randomized controlled trials Good evidence for clinical practice. Results There were 2 systematic reviews, 3 meta-analyzes and 172 randomized controlled trials. After screening, 12 RCTs were finally included and 1 Meta-analysis. The results suggest that pulmonary function in patients with COPD after inhaled salmeterol has significantly improved, clinical symptoms have been alleviated and quality of life has improved. The above evidence combined with the patient’s wishes applied to the patient with good results. Conclusions Salmeterol inhalation in patients with COPD can significantly improve lung function, relieve clinical symptoms and improve quality of life. However, due to some adverse reactions, it should be considered in practical application.