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[目的]分析含加替沙星的四联疗法补救初次根除治疗幽门螺杆菌(H.pylori,Hp)失败的有效性和安全性。[方法]将133例Hp感染初次根除失败患者随机分为治疗组71例,对照组62例。治疗组给予加替沙星、呋喃唑酮、果胶铋、兰索拉唑治疗,对照组给予甲硝唑、呋喃唑酮、果胶铋、兰索拉唑治疗,疗程均为10d。停药4周后复查Hp,分析Hp的根除率及不良反应发生率。[结果]治疗组、对照组Hp根除率分别为91.18%、81.67%(P<0.05)。不良反应发生率治疗组为13.23%,对照组为21.67%,2组间差异有统计学意义(P<0.05)。[结论]含加替沙星的四联方案是治疗Hp初次根除失败后的一种安全、有效的补救治疗方案。
[Objective] To analyze the efficacy and safety of quadruple therapy with gatifloxacin in the treatment of failure of H.pylori (H.pylori) primary eradication. [Method] 133 patients with primary eradication failure of Hp infection were randomly divided into treatment group (n = 71) and control group (n = 62). Gatifloxacin, furazolidone, pectin bismuth and lansoprazole were given to the treatment group. Metronidazole, furazolidone, pectin bismuth and lansoprazole were given to the control group for 10 days. After 4 weeks of withdrawal, the Hp was reviewed, and the eradication rate of Hp and the incidence of adverse reactions were analyzed. [Results] The eradication rates of Hp in the treatment group and control group were 91.18% and 81.67%, respectively (P <0.05). The incidence of adverse reactions was 13.23% in the treatment group and 21.67% in the control group, with significant difference between the two groups (P <0.05). [Conclusion] The quadruple protocol with gatifloxacin is a safe and effective remedy for Hp after initial eradication failure.