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目的探讨载脂蛋RE（apoE）基因多态性与Parkinson病及Alzheimer病的关系。方法应用聚合酶链反应-限制性片段氏度多态性（PCR－RFLP）技术检测72名帕金森氏病（PD）、68名Alzheimer病（AD）患者和66名正常老年人的apoE基因型分布。结果PD组apoE2、apoE3、apoE4及AD组apoE4等位基因频率与对照组比较无统计学意义（P＞0.05）；AD组apoE2等位基因频率明显低于对照组（P＜0．01）。结论apoE基因型分布与PD发病无关；与AD发病相关，即apoE2基因可能具有防止AD发病的作用；不支持apoE4是中国人散发性AD发病病危因素的结论。
Objective To investigate the relationship between apolipoprotein RE (apoE) gene polymorphisms and Parkinson’s disease and Alzheimer’s disease. Methods The apoE genotypes of 72 Parkinson’s disease (PD), 68 Alzheimer’s disease (AD) patients and 66 normal controls were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) distributed. Results The frequencies of apoE4 alleles in apoE2, apoE3, apoE4 and AD groups were not significantly different from those in control group (P> 0.05). The frequency of apoE2 allele in AD group was significantly lower than that in control group (P <0.01). Conclusion The distribution of apoE genotype has nothing to do with the pathogenesis of PD. Associated with the pathogenesis of AD, apoE2 may play a role in preventing the onset of AD. It is concluded that apoE4 is not a risk factor for sporadic AD in Chinese.