患者男,72岁,退休干部。主因腹部、双腿外侧皮肤瘙痒1 d入院。4 d前患者因高血压病在我院门诊就诊,既往长期口服硝苯地平缓释片10 mg,bid降压治疗,因其疗效不满意,医生根据患者病情予口服厄贝沙坦(安博维,杭州赛诺菲安万特民生制药有限公司,批号:1797)150 mg,po,qd。患者服药第3天出现皮肤瘙痒,第4天双腿外侧、下腹部及腰部皮肤先后出现大小不一的风团,局部连成片状,面部、眼睑无水肿,于服药第4天入我院诊治。患者既往无药物过敏史,否认摄入 Male patient, 72 years old, retired cadre. Main due to the abdomen, legs outside the skin itching 1 d admission. 4 d patients with hypertension in our clinic, long-term oral administration of nifedipine 10 mg, bid antihypertensive treatment, because of their dissatisfaction, the doctor according to the patient’s condition to oral irbesartan (Ambow , Hangzhou Sanofi Anantt Minsheng Pharmaceutical Co., Ltd., batch number: 1797) 150 mg, po, qd. On the fourth day, the skin outside the legs, the lower abdomen and the lower part of the waist appeared in different sizes. The slices were locally connected and there was no edema on the face and eyelids. On the fourth day after taking the medicine, Diagnosis and treatment. Past history of patients without drug allergy, denied intake