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目的 :了解实验性高胆固醇血症家兔血液流变特性的改变与动脉粥样硬化形成的关系。方法 :健康家兔 80只 ,随机分为实验组 (AG) 6 0只和对照组 (CG) 2 0只。各组又均分为 4个亚组 ,即AG1～AG4和CGl～CG4。AG组每只给予胆固醇粉 1g/d ,在喂养的第 2、4、8和 12周分别观察AGl～CGl、AG2～CG2、AG3～CG3和AG4～CG4的主动脉粥样硬化 (AS)病变及相应血液流变特性的变化。结果 :在兔AS阶段性进程中血清总胆固醇浓度、全血粘度、血浆粘度、红细胞硬度指数、红细胞聚集指数及全血粘弹性呈升高趋势 ,而红细胞变形参数呈下降趋势。低切全血粘度与红细胞聚集指数间 (r =0 .6 2 8,0 .6 84,0 .881,P <0 .0 1)、弹性模量与红细胞硬度指数 (r =0 .5 78～0 .842 ,P <0 .0 5～ 0 .0 0 1)和动粘度 (r=0 .5 13～ 0 .848,P <0 .0 5～ 0 .0 0 1)间均存在正相关关系 ,而红细胞变形参数与高切全血粘度 (r=- 0 .5 91～ - 0 .813 ,P <0 .0 5～ 0 .0 0 1)和弹性模量 (r=- 0 .5 6 9～ - 0 .784,P <0 .0 5～ 0 .0 0 1)间有负相关关系。结论 :除高胆固醇血症外 ,血流变特性特别是红细胞变形能力降低和全血粘弹性的改变亦是AS的重要成因。
Objective: To investigate the relationship between the changes of blood rheology and the formation of atherosclerosis in rabbits with experimental hypercholesterolemia. Methods: Eighty healthy rabbits were randomly divided into experimental group (AG) 60 and control group (CG) 20. Each group was divided into four subgroups, namely AG1 ~ AG4 and CG1 ~ CG4. The rats in AG group were given 1 g / d of cholesterol powder. The aortic atherosclerosis (AS) lesions of AGl-CGl, AG2-CG2, AG3- CG3 and AG4- CG4 were observed at the 2nd, 4th, 8th and 12th weeks And corresponding changes in the rheological properties of blood. Results: Serum total cholesterol concentration, whole blood viscosity, plasma viscosity, erythrocyte hardness index, erythrocyte aggregation index and whole blood viscoelasticity tended to increase in rabbit AS stage process, while erythrocyte deformation parameters showed a decreasing trend. Low-cut whole blood viscosity and erythrocyte aggregation index (r = 0.268,0.684,0.881, P <0.01), elastic modulus and erythrocyte hardness index (r = 0.578 -0.842, P <0.05-0.0.01) and kinematic viscosity (r = 0.513-0.848, P <0.05-0.010), there were positive (R = - 0. 0591 ~ -0.813, P <0.05 ~ 0.010) and elastic modulus (r = - 0), respectively. 5 6 9 ~ - 0 .784, P <0 05 ~ 0 0 0 1). CONCLUSION: In addition to hypercholesterolemia, rheological properties, especially erythrocyte deformability and whole blood viscoelastic changes are also important causes of AS.