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Five new C-8 Mannich base derivatives of irisolidone 2a-2e were synthesized and their nitric oxide(NO)production inhibitory activity was evaluated.Compounds 2a,2b,2c and 2e displayed stronger activities in vitro than the parent compound irisolidone.
Five new C-8 Mannich base derivatives of irisolidone 2a-2e were synthesized and their nitric oxide (NO) production inhibitory activity was evaluated. Compounds 2a, 2b, 2c and 2e displayed more activities in vitro than the parent compound irisolidone.