心钠素(ANP)是心脏分泌的具有利尿利钠降压作用的循环激素,参与体内水电解质平衡的调节,近年发现ANP可影响细胞钙转运,可能参与细胞钙稳态调节,但其机理尚不清楚。 本工作用培养的兔主动脉平滑肌细胞(VSMC)进行实验,分8组:(1)对照组;(2)～(4)ANP组,终浓度分别为 10~(-9)、10~(-8)和10~(-7)mol/L;(5)内皮素(ET) Atrial natriuretic peptide (ANP), a circulating hormone secreted by the heart with antidiuretic effect of diuretic sodium, is involved in the regulation of water and electrolyte balance in vivo. In recent years, it has been found that ANP can affect the calcium transport and may be involved in the regulation of calcium homeostasis. However, Not clear. In this study, cultured rabbit aortic smooth muscle cells (VSMCs) were divided into 8 groups: (1) control group; (2) ~ (4) ANP group, the final concentrations were 10-9, -8) and 10 ~ (-7) mol / L; (5) Endothelin (ET)