急性肾损伤和急性呼吸窘迫综合征是重症监护室最为常见的脏器衰竭，病死率高。肺脏与肾脏共同参与维持机体酸碱平衡，两者都含有庞大的血管网络，互为对方功能衰竭首要的远隔器官效应的靶器官。本文综述肾损伤或急性呼吸窘迫综合征时发生的肺-肾cross-talk的可能发病机制，以加深对两种疾病的认识，改善预后。“,”Acute kidney injury and acute respiratory distress syndrome are the most common organ failure in intensive care unit with high mortality.Both lung and kidney are involved in maintaining acid-base balance in the body, and both organs contain a large vascular network, which is the primary target organ for distant organ effects in the failure of each other.This article reviewed the possible pathogenesis of lung-kidney cross-talk in renal injury or acute respiratory distress syndrome, in order to deepen the understanding of both diseases and improve the prognosis.