E3泛素连接酶Mule通常在人结直肠癌组织中过表达,但其在肠道肿瘤发生中的作用尚不清楚。Dominguez-Brauer等通过体内实验发现,Mule可以通过c-Myc对Wnt信号通路进行调控,从而调节小鼠肠道干细胞和祖细胞的增殖。Mule还可以通过靶向性调控受体酪氨酸激酶EphB3的蛋白酶体和溶酶体降解来调节其受体蛋白水平。在肠道内,EphB/ephrinB相互作用 The E3 ubiquitin ligase, Mule, is usually overexpressed in human colorectal cancer but its role in intestinal tumorigenesis is unclear. Dominguez-Brauer et al. In vivo experiments showed that Mule regulates the Wnt signaling pathway through c-Myc to regulate the proliferation of mouse intestinal stem and progenitor cells. Mule also regulates its receptor protein levels by targeting the proteasome and lysosomal degradation of the receptor tyrosine kinase EphB3. In the gut, EphB / ephrinB interacts