血管瘤是以微血管内皮细胞旺盛增殖和血管生成为主要特征的良性肿瘤,未经控制的血管生成是血管瘤增殖的主要原因。血管内皮生长因子(VEGF)通过与受体结合而选择性作用于血管内皮细胞(ECs),产生促进ECs增殖、迁移、基质降解和血管通透性增高等一系列生物学作用,最终刺激血管生成,从而在血管瘤增殖中起到重要作用。 Hemangiomas are benign tumors characterized by strong proliferation and angiogenesis of microvascular endothelial cells. Uncontrolled angiogenesis is the major cause of proliferation of hemangiomas. Vascular endothelial growth factor (VEGF) acts selectively on vascular endothelial cells (ECs) by binding to receptors, and produces a series of biological effects such as promoting proliferation, migration, matrix degradation and vascular permeability of ECs and ultimately stimulating angiogenesis , Which play an important role in the proliferation of hemangiomas.