论文部分内容阅读
目的:研究牡丹皮有效成分丹皮酚和芍药苷配伍对大鼠血栓形成及血液流变学的影响。方法:丹皮酚和芍药苷配伍高(丹皮酚50mg/kg+芍药苷12.5mg/kg)、中(丹皮酚25mg/kg+芍药苷6.25mg/kg)、低剂量(丹皮酚12.5mg/kg+芍药苷3.125mg/kg),采用大鼠体外血栓形成方法、大鼠动静脉旁路血栓形成方法以及血液流变学测定方法,检测各项指标。结果:丹皮酚和芍药苷配伍的高、中、低剂量组均能显著抑制大鼠体外血栓以及动静脉旁路血栓的长度、湿重及干重(P<0.05或P<0.01),明显降低高、低切变率下的全血黏度(P<0.05或P<0.01),但对血浆黏度的影响,与空白对照组相比,无统计学差异。结论:丹皮酚和芍药苷配伍对大鼠血栓形成及血液流变学指标均有显著的改善作用,为其临床应用奠定了理论基础。
Objective: To study the effect of paeonol and paeoniflorin on thrombosis and hemorheology in rats. METHODS Paeonol and paeoniflorin were combined with high paeonol (50mg / kg paeoniflorin and 12.5mg / kg paeoniflorin), paeonol 25mg / kg + paeoniflorin 6.25mg / kg and low dose paeonol 12.5mg / kg + paeoniflorin 3.125mg / kg). The in vitro thrombosis method, the rat arteriovenous bypass thrombosis method and the hemorheology method were used to detect the indexes. Results: Paeonol and paeoniflorin in high, medium and low dose groups were able to significantly inhibit the thrombus in vitro and the length, wet weight and dry weight of arteriovenous bypass thrombosis (P <0.05 or P <0.01), significantly Reduce the whole blood viscosity at high and low shear rate (P <0.05 or P <0.01), but have no significant difference on the plasma viscosity compared with the blank control group. Conclusion: The combination of paeonol and paeoniflorin can significantly improve thrombosis and hemorheology in rats, which has laid a theoretical foundation for its clinical application.