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细菌内毒素(Endotoxin)是迄今发现的生物活性最为广泛的物质之一,内毒素拮抗剂的研究已成为生命科学的热门话题。中药化学成分是中药药理作用的物质基础。板蓝根有机酸;山莨菪碱;苦参碱;川芎嗪;秋水仙碱及甘氨酸等18个中药化学成分分别从破坏内毒素分子结构、抑制内毒素诱导的炎性介质的合成和释放及降低内毒素的致热性和致死性等不同途径呈现其抗内毒素作用。但大多数仍局限于实验室,今后不仅应扩大研究范围,还应加强临床应用研究。
Bacterial endotoxin (Endotoxin) is one of the most widely discovered bioactive substances to date. The study of endotoxin antagonists has become a hot topic in the life sciences. The chemical composition of Chinese medicine is the material basis of the pharmacological effects of Chinese medicine. Radix isatidis organic acids; anisodamine; matrine; ligustrazine; colchicine and glycine 18 Chinese chemical components from the destruction of the molecular structure of endotoxin, inhibition of endotoxin-induced synthesis and release of inflammatory mediators and reduce endotoxin The different sources of heat and lethality present their antiendotoxin effects. However, most of them are still confined to laboratories. In the future, they should not only expand the scope of research, but also strengthen clinical application research.