脑型疟(CM)是人体恶性疟原虫感染常见的致死性并发症。CM的鼠模型用CBA小鼠感染伯氏疟原虫ANKA株,已广泛应用,它具有某些人体CM的特点。通过这种模型,阐明了CM发病的多方面情况,但是对于原虫血症的动力学与CM发生的关系,感染后的病理学,持续性变化等均未详细地叙述。因而作者对感染伯氏疟原虫的动物模型进行了一系列深入的研究。 Cerebral malaria (CM) is a common fatal complication of human P. falciparum infection. CM Mouse Model CBA mice infected with P. berghei ANKA strain have been used extensively and have the characteristics of certain human CMs. Through this model, many aspects of the pathogenesis of CM are elucidated. However, the relationship between the kinetics of protozoalosis and the occurrence of CM, the pathology after infection, and the persistent changes are not described in detail. The authors therefore conducted a series of in-depth studies on animal models of Plasmodium berghei infection.