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观察１２创先天性心脏病（ＣＨＤ）合并肺动脉高压（ＰＨ）患几吸入一氧化氮（ＮＯ）２０分钟后，肺动脉（ＰＡ）、肺毛细管（ＰＷ）、主动脉（ＡＯ）的压力和阻力改变情况，以及ＡＯ血氧饱和度、心率（ＨＲ）、高铁血红蛋白浓度的改变情况，并与１７例同类患儿静注立其丁作对照。结果显示吸入ＮＯ浓度在（３５～５５）×１０－６（即百万分之一，ｐｐｍ）时，可显著降低ＰＡ压力（Ｐ＜０．０５），而对ＡＯ压力无影响；对照组降低ＰＡ压力非常显著，但降ＡＯ压力亦非常显著（Ｐ均＜０．０１）。提示ＮＯ有可能是一种比较理想的选择性降低ＰＡ压力的因子，在一定浓度范围内无明显的毒副作用，但维持作用时间较短。
To observe the changes of pressure and resistance of the pulmonary artery (PA), pulmonary capillary (AQ) and pulmonary artery (PA) in patients with congenital heart disease (CHD) and pulmonary hypertension (PH) after a few minutes of inhalation of nitric oxide The changes of oxygen saturation (AO), heart rate (HR) and methemoglobin concentration were compared with those of 17 children with similar statics. The results showed that the inhalation of NO concentration (35 ~ 55) × 10-6 (ppm), can significantly reduce PA pressure (P <0.05), but no effect on AO pressure; control group decreased PA pressure is very significant, but the pressure of lowering AO is also very significant (P <0.01). Prompted that NO may be an ideal selective reduction of PA pressure factor, in a certain concentration range no obvious side effects, but the maintenance effect is shorter.