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选健康雄性Ｗｉｓｔａｒ大鼠１２２只，用脑室微量注射和放射免疫等分析方法，观察了中枢内、外源性神经降压素（ＮＴ）在大鼠束缚加水浸诱导的应激性胃溃疡中的作用。结果表明：（１）在大鼠应激性胃溃疡产生的同时，其血浆内神经降压素样免疫活性物（ＮＴＬＩ）的含量明显减少（Ｐ＜０．０５），而下丘脑、中脑、脑桥、延脑和垂体中ＮＴ－ＩＲ含量则明显升高（Ｐ＜０．０１）；（２）侧脑室注射抗ＮＴ血清后，大鼠应激性胃溃疡的产生明显加重（Ｐ＜０．０５）；（３）侧脑室微量注射ＮＴ，大鼠应激性胃溃疡的产生明显减轻，且呈明显的量效依赖关系（Ｐ＜０．０５～０．０１）；（４）经皮下注射消炎痛后，侧脑室注射ＮＴ，ＮＴ的胃粘膜细胞保护作用消失（Ｐ＞０．０５）。结果提示：大鼠中枢内、外源性ＮＴ对胃粘膜细胞具有保护作用，该保护作用可能与前列腺素的合成有关。
A total of 122 healthy male Wistar rats were randomly divided into three groups: control group (n = 12) and control group (n = 12). The contents of central and exogenous neurotensin (NT) effect. The results showed that: (1) NTLI was significantly decreased in rats with stress ulcer (P <0.05), while hypothalamus, midbrain (P <0.01); (2) After intracerebroventricular injection of anti-NT serum, the occurrence of stress gastric ulcer was significantly increased (P <0, P <0.01) .05). (3) NT induced by lateral microinjection into the lateral ventricle significantly reduced the stress-induced gastric ulcer (P <0.05-0.01); (4) After injection of indomethacin, the protective effects of NT and NT on gastric mucosal cells disappeared (P> 0.05). The results suggest that exogenous NT has a protective effect on gastric mucosal cells in rats, which may be related to the prostaglandin synthesis.