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目的对组织微阵列技术研究肿瘤转移相关基因在鼻咽癌中的临床意义进行分析研究。方法选取我院收治的156例鼻咽癌患者作为研究对象,使用组织微阵列技术对肿瘤转移相关因素进行研究。结果模型基质金属蛋白酶-1和模型细胞骨架连结蛋白埃滋蛋白在鼻咽癌组织中的阳性表达明显高于鼻咽炎性上皮;鼻咽癌组织中转移抑制因子和金属蛋白酶组织抑制因子-2蛋白的阳性表达明显低于其在癌旁鼻炎上皮组织和鼻咽炎性黏膜上皮中的表达(P<0.05)。模型基质金属蛋白酶-2和细胞粘附因子蛋白在鼻咽癌、癌旁鼻炎上皮和慢性炎性鼻炎上皮组织中的表达比较,数据差异不明显(P>0.05)。结论多个肿瘤转移基因的蛋白质表达在鼻咽癌淋巴结转移和进展的过程中起到了重要的作用,模型基质金属蛋白酶-1可以作为临床预测鼻咽癌淋巴转移的分子标志。
Objective To analyze the clinical significance of tissue microarray in the study of tumor metastasis-related genes in nasopharyngeal carcinoma. Methods 156 patients with nasopharyngeal carcinoma admitted to our hospital were selected as research objects, and tissue microarray was used to study the related factors of tumor metastasis. Results The positive expressions of MMP-1 and E-cadherin in nasopharyngeal carcinoma tissues were significantly higher than those in nasopharyngeal epithelium; the metastasis suppressor and metalloproteinase-2 The positive expression was significantly lower than its expression in paracancer rhinitis epithelial tissue and nasopharyngeal mucosa (P <0.05). The expression of MMP-2 and cell adhesion molecule in nasopharyngeal carcinoma, paracancer rhinitis and chronic inflammatory rhinitis epithelial tissue were not significantly different (P> 0.05). Conclusion The protein expression of multiple tumor metastasis genes plays an important role in the process of lymph node metastasis and progression of nasopharyngeal carcinoma. The expression of MMP-1 may be used as a molecular marker for clinical prediction of lymphatic metastasis of nasopharyngeal carcinoma.