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镍化合物广泛用于现代工业,高消耗含镍化合物的产品不可避免地会导致环境污染。人类接触镍化合物主要是通过吸入和摄入,尤其镍冶金行业的工人接触更多,在矿工和镍冶炼油厂的工人中肺癌和鼻咽癌风险增高[1],国际癌症研究中心(IARC)于1990年正式确定镍化合物中的硫化镍(Ni3S2)和三氧化二镍(Ni2O3)为第1类致癌物。镍化合物作为一类典型的致癌物,通过干扰细胞抗氧化系统使活性氧蓄积或通过多种途径产生自由基,导致
Nickel compounds are widely used in modern industry, and high consumption of nickel compounds inevitably leads to environmental pollution. Human exposure to nickel compounds has been associated with increased exposure of lung cancer and nasopharyngeal cancer among workers at miners and nickel smelters, mainly through inhalation and ingestion, particularly among workers in the nickel-metallurgical industry [1], the International Agency for Research on Cancer (IARC) Nickel sulphide (Ni3S2) and nickel oxide (Ni2O3) were officially identified as Class 1 carcinogens in 1990. Nickel compounds as a typical class of carcinogens, by interfering with cellular antioxidant systems make active oxygen accumulation or by a variety of ways to produce free radicals, resulting in