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目的：分析肾移植术后病人口服环孢素和硫唑嘌呤引起肝功能损害情况。方法：肾移植术后病人６８例（男性５４例，女性１４例；年龄４１±ｓ７ａ），口服环孢素４．０ｍｇ／（ｋｇ·ｄ），ｐｏ，ｑｄ，每隔２ｗｋ减０．５ｍｇ／（ｋｇ·ｄ），最低剂量１．０ｍｇ／（ｋｇ·ｄ）；硫唑嘌呤与环孢素同时服，剂量为５０ｍｇ，ｐｏ，ｑｄ。根据不同疗程分为３组，第１组为≤９０ｄ；第２组为９１～１８０ｄ；第３组为＞１８０ｄ。结果：肾移植病人服环孢素和硫唑嘌呤前后肝功能损害发生率Ｐ＜０．０１，第１，第２组与第３组比较发生率均差异显著（Ｐ＜０．０５）。结论：肾移植病人口服２药后均有不同程度肝损害。
OBJECTIVE: To analyze the liver damage induced by oral cyclosporin and azathioprine in patients after renal transplantation. Methods: Sixty-eight patients (54 males and 14 females; age 41 ± s7a) were enrolled in this study. Oral cyclosporine 4.0 mg / (kg · d), po, qd and 0.5 mg / (Kg · d), the lowest dose of 1.0mg / (kg · d); azathioprine and cyclosporine at the same time, the dose of 50mg, po, qd. According to the different course of treatment, the patients were divided into three groups, the first group was ≤90d; the second group was 91 ~ 180d; the third group was> 180d. Results: The incidence of liver dysfunction before and after cyclosporin and azathioprine treatment in renal transplant recipients was P <0.01. There was significant difference (P <0.05) between the first and second groups and the third group. CONCLUSIONS: All renal transplant recipients have varying degrees of liver damage after oral administration of 2 medications.