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树突状细胞 (DC )的发育可分为未成熟和成熟两个阶段 ,未成熟DC在捕捉抗原后向外周淋巴组织的T细胞区迁移并成熟 ,成熟DC能表达丰富的MHC分子和协同刺激分子。未成熟DC通过诱导无能的和调节性T细胞导致免疫耐受 ,而成熟DC具有超强的激活初始T细胞能力。DC至少可分为三个亚群 ,不同亚群的DC在激活Th1/Th2、CTL应答方面存在差异 ,但最近的研究显示DC对T细胞应答类型的调控受多种因素的综合影响 :包括微生物的产物或佐剂、DC表面的信号受体、DC亚群、局部的微环境和附近T细胞及其他细胞产生的细胞因子。因此 ,目前认为DC的功能具有可塑性
The development of dendritic cells (DCs) can be divided into immature and mature stages. Immature DCs migrate and mature into T lymphocyte regions of peripheral lymphoid tissues after antigen capture, and mature DCs can express abundant MHC molecules and coordinately stimulate molecular. Immature DCs induce immune tolerance by inducing incompetent and regulatory T cells, whereas mature DCs have superior ability to activate naive T cells. DCs can be divided into at least three subgroups, and DCs in different subgroups differ in the activation of Th1 / Th2 and CTL responses. However, recent studies have shown that the regulation of DC response to T cell types is influenced by a combination of factors including microbial DCs, DC subpopulations, local microenvironments and nearby T cells and other cell-derived cytokines. Therefore, the function of DC is currently considered plastic