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前S1蛋白(PreS1)是组成乙肝病毒(HBV)外膜蛋白的重要成分之一,其含有肝细胞膜受体,对HBV附着于肝细胞和诱导特异性免疫应答具有重要作用[1-3]。近年来,作为一种新的HBV检测指标,PreS1的临床价值越来越受到人们的关注[4]。HBV血清标志物(HBV-M),即“乙肝三系”中的“e系统”作为临床上观察HBV存在及动态变化情况的常规检查项目,被得到广泛的应用。近年来随着HBV变异导致乙型肝炎病毒e抗
PreS1 (PreS1) is an important component of the outer membrane protein of hepatitis B virus (HBV), which contains hepatocyte membrane receptors and plays an important role in the attachment of HBV to hepatocytes and induction of specific immune responses [1-3]. In recent years, as a new indicator of HBV testing, the clinical value of PreS1 has drawn more and more attention [4]. HBV serum markers (HBV-M), that is, “e system ” in “Hepatitis B three lines ” are widely used as routine examination items for observing the existence and dynamic changes of HBV clinically. In recent years, HBV mutations lead to hepatitis e virus