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目的 探讨在胃癌发生发展过程中MG7抗原表达的动态变化及意义。方法 采用免疫组化技术及组化技术检测 40 6例胃黏膜MG7抗原的表达情况及肠上皮化生类型。结果 从组织学角度观察 ,正常胃黏膜→肠上皮化生及异型增生→胃癌 ;Ⅰ、Ⅱ型肠上皮化生→Ⅲ型肠上皮化生 ,MG7抗原阳性表达率依次上升 (P <0 .0 1)。从临床疾病角度观察 ,浅表性胃炎→萎缩性胃炎→胃癌 ,MG7抗原阳性表达率依次上升 (P <0 .0 1)。结论 MG7抗原与胃癌发生发展有良好的相关性 ,对胃癌具有较高的特异性 ;对萎缩性胃炎 ,Ⅲ型肠上皮化生与异型增生进行严密监测有可能提高早期胃癌的检出率 ,MG7在胃癌前疾病动态随访中具有重要应用价值。
Objective To investigate the dynamic changes and significance of MG7 antigen expression during the development of gastric cancer. Methods 40 cases of gastric mucosa MG7 antigen expression and intestinal metaplasia type were detected by immunohistochemistry and histochemical techniques. Results From the histological point of view, normal gastric mucosa → intestinal metaplasia and dysplasia → gastric cancer; type Ⅰ and Ⅱ intestinal metaplasia → type Ⅲ intestinal metaplasia, MG7 antigen positive rate (P <0. 0 1). From the perspective of clinical disease, the positive expression rate of MG7 antigen increased from superficial gastritis → atrophic gastritis → gastric cancer (P <0.01). Conclusion The MG7 antigen has a good correlation with the occurrence and development of gastric cancer and has a high specificity for gastric cancer. The close monitoring of atrophic gastritis, type Ⅲ intestinal metaplasia and dysplasia may improve the detection rate of early gastric cancer, MG7 In the dynamic follow-up of gastric cancer has important application value.