自发性气胸经保守疗法后持续漏气5～7天以上或反复发作,就有开胸作外科修补手术的指征。但以化学性胸膜粘合术代替则可避免手术痛苦和危险。过去曾应用硝酸银、白陶土、滑石粉和盐酸阿的平作粘合术硬化剂,因都有不可避免的严重反应且疗效不够肯定而已被放弃。本文作者用四环素作硬化剂治疗反复发作的自发性气胸2例,收到显著疗效。作者指出虽然四环素同样产生局部疼痛和发热反应,但只要术前适当处理可无疼痛感觉,发热也是短暂的。具体的做法是:先用盐酸吗啡加安定静脉术前给药,而后用盐酸四环素600mg 稀释于20ml 生理盐水由胸管滴入患侧胸腔,在4小时内帮助患者不断翻身,变换体位。滴注后次 Spontaneous pneumothorax after conservative treatment continued to leak more than 5 to 7 days or recurrent, there are indications for surgical repair of thoracotomy. However, the replacement of chemical pleural adhesion surgery can avoid the pain and danger. Past use of silver nitrate, kaolin, talcum powder and hydrochloric acid for the adhesive curing agent, because of the inevitable serious reaction and the effect is not sure and has been abandoned. The authors used tetracycline as a sclerotherapy in the treatment of recurrent spontaneous pneumothorax in 2 cases, received a significant effect. The authors note that although tetracycline also produces local pain and fever, it is transient as long as there is no painful sensation before surgery. The specific approach is: first with morphine hydrochloride plus stable intravenous administration, and then with tetracycline hydrochloride 600mg diluted in 20ml normal saline from the chest tube into the affected side of the chest, in 4 hours to help patients stand up, changing position. The next infusion