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v-erb-A,这种具有微弱生物作用而功能未知的癌基因一直被人忽视。然而今天,随着v-erb-A基因和那些编码甾体激素受体基因间的结构亲缘关系的发现,此基因在协调细胞特有功能的基因群中占有一定的地位。和其他逆转录病毒癌基因一样,v-erb-A来源于细胞原癌基因(c-erb-A)的转导。但v-erb-A的特点是它与另一癌基因——更重要的v-erb-B(由编码细胞表面的表皮生长因子受体的基因转导而来)共同构成禽类红母细胞增多症病毒(AEV)基因组。AEV能在鸡中引起红白血病,能转化培养中的红系造血细胞。AEV引起恶性转化的主要责任在于v-erb-B,它阻碍了红系前体细胞的成熟。然而,
v-erb-A, an oncogene with a weak biological role and unknown function, has been neglected. Today, however, with the discovery of the structural relationship between the v-erb-A gene and those encoding steroid hormone receptor genes, this gene occupies a certain position in the gene cluster that coordinates cell-specific functions. Like other retroviral oncogenes, v-erb-A is derived from the transduction of the cellular proto-oncogene (c-erb-A). But the hallmark of v-erb-A is that it shares avian reds with another oncogene, the more important v-erb-B (transduced from the gene encoding the epidermal growth factor receptor on the cell surface). Disease virus (AEV) genome. AEV can cause erythroleukemia in chickens and can transform erythroid hematopoietic cells in culture. The main responsibility of AEV for malignant transformation lies in v-erb-B, which impedes the maturation of erythroid precursor cells. however,