单核细胞与动脉粥样硬化的发生与发展及血栓形成关系密切。在生理性止血以及损伤性刺激引起的血栓形成中 ,组织因子 (TF)均是凝血的启动因子。动脉粥样硬化斑块中所含的单核细胞 ,巨噬细胞以及外周血液中的单核细胞 ,对急性冠脉事件起重要作用。本文从单核细胞的基础表达 ,诱导表达 ,单核细胞与其它细胞的交互作用以及TF表达的抑制几个方面介绍单核细胞组织因子的表达及其调控。 Monocytes and atherosclerosis occurrence and development and thrombosis are closely related. Tissue factor (TF) is a coagulation-promoting factor in both physiological hemostasis and thrombosis caused by damaging stimuli. Monocytes, macrophages and monocytes in peripheral blood contained in atherosclerotic plaques play an important role in acute coronary events. In this paper, monocytes from the basic expression, induced expression of monocytes and other cells interaction and inhibition of TF expression in several aspects of monocyte tissue factor expression and regulation.