nm23-H1基因已被证明是肿瘤转移抑制基因,它的结构和功能的异常与癌细胞的侵袭和转移能力密切相关。研究证明nm23-H1基因的低表达和杂合性缺失与肺癌的高转移性和预后不良有密切关系。周清华等推测nm23-H1基因可能是“肺癌转移抑制级联”中的关键基因和上游基因,为了进 The nm23-H1 gene has been shown to be a tumor metastasis suppressor gene whose structural and functional abnormalities are closely related to the invasion and metastasis of cancer cells. Studies have shown that the low expression of nm23-H1 gene and loss of heterozygosity and lung cancer is closely related to the high metastasis and poor prognosis. Zhou Qinghua speculated nm23-H1 gene may be “lung cancer metastasis suppression cascade” in the key genes and upstream genes, in order to enter