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目的:探讨在瑞舒伐他汀不同剂量下对治疗对冠心病合并高血脂症的老年患者的血脂功能水平的影响。方法:回顾性选取我院接诊的冠心病老年患者120例,且经过血脂检查全部属于高血脂症,按照使用瑞舒伐他汀的剂量不同,分为三组各40例患者,分别给予剂量为5 mg、10 mg和20 mg,以治疗后2个月为观察期,比较治疗前后患者的血脂水平变化及临床有效率。结果:(1)20mg组患者的血脂水平HDL-C[(1.17±0.62)mmol/L]比其他两组明显上升,LDL-C[(3.67±0.83)mmol/L]、TC[(4.36±0.96)mmol/L]、TG[(1.68±0.94)mmol/L]也下降较另外两组明显(P均<0.05);(2)20 mg组的治疗有效率为(97.5%)明显高于5mg组(87.5%)和10mg组(85.0%)(P均<0.05)。结论:瑞舒伐他汀治疗冠心病合并高血脂症的老年患者,选择20 mg剂量可显著改善患者的血脂水平,且具有较高的治疗有效率,是一种使用方便,临床效果明显的给药方式。
Objective: To investigate the effect of rosuvastatin on blood lipid levels in elderly patients with coronary heart disease complicated with hyperlipidemia under different doses of rosuvastatin. Methods: A retrospective selection of 120 cases of elderly patients admitted to our hospital coronary heart disease, and after lipids are all hyperlipidemia, according to the different doses of rosuvastatin, divided into three groups of 40 patients were given a dose of 5 mg, 10 mg and 20 mg, respectively, two months after treatment for the observation period, before and after treatment in patients with changes in blood lipid levels and clinical efficiency. The serum levels of HDL-C [(1.17 ± 0.62) mmol / L] in 20 mg group were significantly higher than those in the other two groups. LDL-C [ 0.96) mmol / L] and TG [(1.68 ± 0.94) mmol / L] were significantly lower than those in the other two groups (all P <0.05); (2) The treatment efficiency was significantly higher 5 mg group (87.5%) and 10 mg group (85.0%) (P <0.05). Conclusion: The rosuvastatin treatment of elderly patients with coronary heart disease and hyperlipidemia, the choice of 20 mg dose can significantly improve the patient’s blood lipids, and has a high therapeutic efficiency, is a convenient, clinically effective dosing the way.