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目的 探讨狼疮性肾炎（ＬＮ）患者的淋巴细胞亚群和免疫球蛋白（Ｉｇ）的变化及其意义。方法采用淋巴细胞的膜抗原双标记染色法及ＥＬＩＳＡ，对６０例ＬＮ患者的细胞与体液免疫功能进行前瞻性研究。结果①与对照组相比较，活动期ＬＮ患者的ＣＤ３＋ＣＤ４＋细胞的比率（Ａ组：伴肾病综合征者）为（ｌ６．３ ±７．９）％，Ｂ组（不伴肾病综合征者）为（２０．８±１０．１）％］和ＣＤ１６＋＋ＣＤ５６＋细胞的比率［Ａ组为（８．６±５．７）％，Ｂ组为（１５．２±６．２）％明显减少；ＣＤ３+ ＣＤ8+”细胞的比率［Ａ组为（４８．３±１０．７）％，Ｂ组为（３５．９±９．８）％］明显增高；ＣＤ３+ ＣＤ４+ ／ＣＤ３+ ＣＤ８＋细胞的比值＜１（Ａ组为０．４３±０．２１，Ｂ组为０．８７±０．２５），且Ａ组与８组相比较差异明显（Ｐ＜０．０５）。②与活动期ＬＮ患者相比较，治疗后处于稳定期的 ＬＮ患者 ＣＤ３＋ＣＤ４＋细胞的比率卜组为（２８．８±８．ｌ）％，Ｂ组为（３２．８± ７．ｌ）％］和 ＣＤ１６＋＋ＣＤ５６＋细胞的比率［Ａ组为（１８．９ ± １２．５）％，Ｂ组为（２４．０±８． ９）％，以及 ＣＤ３＋ＣＤ４＋／ＣＤ３＋ＣＤ８＋细胞的比值（Ａ组为 ０．９７±２．３，Ｂ组
Objective To investigate the changes of lymphocyte subsets and immunoglobulin (Ig) in patients with lupus nephritis (LN) and its significance. Methods The cellular and humoral immunity of 60 patients with LN were prospectively studied by dual labeling of lymphocyte membrane antigen and ELISA. Results ① Compared with the control group, the percentage of CD3 + CD4 + cells in active LN patients (group A: patients with nephrotic syndrome) was (l6.3 ± 7.9)%, while those in group B (patients without nephrotic syndrome) were (20.8 ± 10.1)%] and CD16 + + CD56 + cells in group A (8.6 ± 5.7)% and group B (15.2 ± 6.2)% respectively. CD3 + CD8 + "The ratio of cells in group A was (48.3 ± 10.7)%, in group B (35.9 ± 9.8)%], and the ratio of CD3 + CD4 + / CD3 + CD8 + cells was less than 1 ( A group was 0.43 ± 0.21, B group was 0.87 ± 0.25), and the difference between group A and group 8 was significant (P <0.05) .②Compared with active LN, The percentage of CD3 + CD4 + cells in stable LN patients after treatment was (28.8 ± 8.1)% in group B and (32.8 ± 7.l)% in group B) The ratio of 6+ cells was (18.9 ± 12.5)% in group A and (24.0 ± 8.9)% in group B, and the ratio of CD3 + CD4 + / CD3 + CD8 + cells in group A was 0.97 ± 2. 3, B group