【摘 要】
：
目的 探讨抑郁症严重程度与患者认知功能及事件相关电位(ERP-P300)的相关性.方法 选择本院2018年2月～2020年2月期间收治的84例抑郁症患者作为研究对象,根据汉密尔顿抑郁量表(HAMD)评分分为重度组(28例)和轻中度组(56例);同时选择一般资料相匹配的40例健康人群设为对照组.采用重复性成套神经心理状态测验(RBANS)评估患者认知功能,采用Viking Quest 4通道肌电诱发电位仪评估患者ERP-P300,采用Pearson相关分析法分析各指标间的相关性.结果 (1)重度和轻中度组的
【机 构】
：
河南大学第一附属医院,开封,475001
论文部分内容阅读
目的 探讨抑郁症严重程度与患者认知功能及事件相关电位(ERP-P300)的相关性.方法 选择本院2018年2月～2020年2月期间收治的84例抑郁症患者作为研究对象,根据汉密尔顿抑郁量表(HAMD)评分分为重度组(28例)和轻中度组(56例);同时选择一般资料相匹配的40例健康人群设为对照组.采用重复性成套神经心理状态测验(RBANS)评估患者认知功能,采用Viking Quest 4通道肌电诱发电位仪评估患者ERP-P300,采用Pearson相关分析法分析各指标间的相关性.结果 (1)重度和轻中度组的HAMD评分高于对照组(P＜0.05);重度和轻中度组的RBANS各项评分(即刻记忆、视觉广度、语言功能、注意、延时记忆评分)和总分低于对照组,且重度组的评分低于轻中度组(P＜0.05).(2)重度和轻中度组P3a、P3b、N2的潜伏期高于对照组,且重度组的潜伏期高于轻中度组(P＜0.05);重度和轻中度组P3a、P3b、N2的波幅低于对照组,且重度组的波幅低于轻中度组(P＜0.05).(3) HAMD评分与RBANS评分呈显著负相关;HAMD评分与P3a、P3b、N2波幅呈负相关,与P3a、P3b、N2潜伏期呈正相关,RBANS评分与P3a、P3b、N2波幅呈正相关,与P3a、P3b、N2潜伏期呈负相关(P＜0.05).结论 抑郁症患者均存在不同程度的认知功能损害,且抑郁程度越高其认知功能损害越严重,ERP-P300可反映抑郁症患者认知功能的损害程度.
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