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本文对1963年至1969年患肾病综合征未经筛选的183例患儿进行了回顾性研究。这些病人主要来源于英国东南部和中部两个地区。对152例进行了随访,有完整的记录。结果:在152例中,男108例,女44例(比例为2.4/1)。随访年龄为14～32岁。首次发病年龄为11个月至15岁,多数发病年龄为3～4岁,与过去报道一致。全部病例均作肾活检。99例(占65％)在首次发病时进行,其余53例在首次发病后6个月至13年(平均4.5年)进行。肾活检均显示微小病变,并且常规给予激素治疗。所有病人在整个病程中自始至终均对激素敏感。随访时,有127例尿蛋白阴性,达到临床缓解。另外4例缓解病人,出现高血压(BP>150/90mnHg)但肾功能正常,确定为原发性高血压。
This article retrospectively reviewed 183 infants who had nephrotic syndrome without screening between 1963 and 1969. These patients mainly come from the southeastern and middle parts of England. 152 cases were followed up, there is a complete record. Results: Among 152 cases, 108 were male and 44 were female (ratio was 2.4 / 1). Follow-up was 14 to 32 years old. The first age of onset is 11 months to 15 years old, the majority of the onset age of 3 to 4 years old, consistent with the past reports. All cases were renal biopsy. Ninety-nine (65%) were performed at the first onset and the remaining 53 were performed six months to 13 years after the initial onset (mean, 4.5 years). Renal biopsy showed minimal change and hormone therapy was routinely given. All patients are hormone sensitive throughout the course of the disease. At follow-up, 127 cases of urinary protein negative, reaching clinical remission. The other 4 patients were relieved, with hypertension (BP> 150 / 90mnHg) but normal renal function, identified as essential hypertension.