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原发性中枢神经系统淋巴瘤(PCNSL)恶性度高,预后较差。PCNSL目前无标准治疗方案,单纯手术或单纯放疗效果较差,以氨甲喋呤(HD-MTX)为基础的综合治疗可改善患者生存率。综合化疗后的放疗以全脑放疗为首选,但放疗可导致老年患者神经毒性。化疗后自体干细胞移植及靶向药物可改善患者预后,并可降低神经毒性发生率。
Primary central nervous system lymphoma (PCNSL) has a high degree of malignancy and a poor prognosis. PCNSL is currently no standard treatment options, surgery alone or radiotherapy less effective, methotrexate (HD-MTX) -based comprehensive treatment can improve patient survival. Radiotherapy combined with chemotherapy is the first choice of whole brain radiotherapy, but radiotherapy can lead to neurotoxicity in elderly patients. Chemotherapy after autologous stem cell transplantation and targeted drugs can improve the prognosis of patients, and can reduce the incidence of neurotoxicity.