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目的 探讨地高辛中毒的原因。方法 调查分析 33例地高辛中毒者的临床资料。结果 33例地高辛中毒患者年龄 2 2～ 89(6 2 .2± 15 .7)岁。平均中毒血药浓度为 (4 .0± 1.6 6 )ng·mL-1。多数患者均合并多种疾病 ,伴有严重器质性心脏病 2 7例 ,肝肾功能不全 2 3例 ,电解质紊乱 11例。此外 ,超量用药和药物相互作用 ,致使地高辛血药浓度增高等因素均与地高辛中毒有关。结论 地高辛中毒因素往往是多方面的 ,因而在使用地高辛时 ,应注意患者生理、病理状况及药物相互作用 ,及时监测血药浓度并调整用药方案 ,对防止中毒的发生极为重要
Objective To investigate the causes of digoxin toxicity. Methods To investigate the clinical data of 33 cases of digoxin poisoning. Results 33 cases of digoxin poisoning patients aged 2 2 ~ 89 (62.2 ± 15.7) years old. The mean plasma concentration of poisoning was (4.0 ± 1.6 6) ng · mL-1. Most patients were complicated by a variety of diseases, with severe organic heart disease in 27 cases, 23 cases of liver and kidney dysfunction, electrolyte imbalance in 11 cases. In addition, excessive drug use and drug interactions, resulting in digoxin plasma concentration and other factors are related to digoxin poisoning. ConclusionDidoxin poisoning factors are often multifaceted, so when digoxin, should pay attention to the patient’s physical, pathological conditions and drug interactions, timely monitoring of blood concentration and adjust the drug program, to prevent the occurrence of poisoning is extremely important