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目的:探讨降钙素原(PCT)在重症腹膜炎早期诊断和治疗效果判断中的临床意义。方法:选取2011年3月至2014年9月本院就诊的128例重症腹膜炎患者作为治疗组,并选取同期来我院体检的健康志愿者128例作为对照组,比较治疗组和对照组之间PCT水平;通过治疗后,比较好转组和恶化组患者之间PCT水平的差异。结果:治疗组患者治疗后各时段的PCT水平均显著高于对照组,差异有统计学意义(P<0.05),治疗组患者的血清PCT水平在治疗后第1 d开始下降,于第1-3 d PCT水平下降速度较快,之后下降速度减缓。两组患者治疗后各时段PCT水平明显低于治疗前,且差异均具有统计学意义(P<0.05)。好转组患者治疗后各时段PCT水平显著低于恶化组患者,差异具有统计学意义(P<0.05),其中好转组患者血清PCT水平在治疗后第1 d开始下降,恶化组患者血清PCT水平在治疗后第1 d开始升高。与治疗前相比,好转组患者治疗后各时段PCT水平明显下降,而恶化组患者治疗后各时段PCT水平显著上升,且差异均具有统计学意义(P<0.05)。结论:PCT水平不仅是重症腹膜炎的一个重要指示物,也是治疗效果的一个有效指标。
Objective: To investigate the clinical significance of procalcitonin (PCT) in early diagnosis and treatment of severe peritonitis. Methods: A total of 128 patients with severe peritonitis treated in our hospital from March 2011 to September 2014 were enrolled as the treatment group, and 128 healthy volunteers were selected as the control group during the same period. The comparison between the treatment group and the control group PCT levels; after treatment, the differences in PCT levels between the better and worse patients were compared. Results: The levels of PCT in the treatment group were significantly higher than those in the control group at each time point after treatment (P <0.05). The serum PCT level of the treatment group began to decrease on the 1st day after treatment, 3 d The PCT level declines faster and then declines more slowly. The PCT levels of the two groups after treatment were significantly lower than those before treatment, and the differences were statistically significant (P <0.05). The PCT level of patients in the remission group was significantly lower than that of the patients in the deteriorated group after treatment (P <0.05), and the serum PCT level decreased in the remission group at the first day after treatment. The serum PCT level in the patients in the remission group was The first day after treatment began to rise. Compared with those before treatment, the PCT levels in each group were significantly decreased after treatment, while those in the worsened group were significantly increased at different time points after treatment (P <0.05). Conclusions: PCT levels are not only an important indicator of severe peritonitis but also a valid indicator of treatment outcome.