B超和CT是原发性肝癌（HCC）的主要影像学诊断方法，但B超难以检出等回声光团的小肝癌患者。血清AFP水平是HCC的重要标志物，但大约40％的早期HCC和15％～20％的进展期HCC患者AFP水平正常[1]，故也不是检测小HCC最敏感的指标。近年来研究发现血清α－L－岩藻糖昔酶（AFU）活力 B-ultrasonography and CT are primary diagnostic imaging methods for primary liver cancer (HCC), but B-ultrasonography is difficult to detect small hepatocellular carcinoma patients with echogenic light masses. Serum AFP levels are important markers of HCC, but about 40% of early HCC and 15% to 20% of advanced HCC patients have normal AFP levels [1], so it is not the most sensitive indicator for detecting HCC. Recent studies have found that serum alpha-L-fucosidase (AFU) activity