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目的:优化复方延胡索止痛涂膜剂的成膜材料处方。方法:选择聚乙烯醇124(PVA 124)和白芨胶为成膜材料,采用正交试验,以PVA 124、白芨胶、甘油和无水乙醇的用量为考察因素,通过对成膜时间和外观性状指标进行综合评分,筛选出最佳成膜材料的组成。结果:最佳成膜材料的组成为:PVA 124 8 g、白芨胶1 g、甘油2 ml、无水乙醇15 ml。结论:优选的成膜材料可用于复方延胡索止痛涂膜剂的制备。
Objective: To optimize the prescription of compound fumarate analgesic film-forming material. Methods: Polyvinyl alcohol 124 (PVA 124) and Baijiao gum were used as film-forming materials. The orthogonal experiment was used to investigate the effects of PVA 124, Baijiao gum, glycerin and absolute ethanol on the film formation time and appearance The index was scored comprehensively to screen the composition of the best film-forming material. Results: The optimum composition of the film-forming material was: PVA 124 8 g, Baijiao gum 1 g, glycerin 2 ml, ethanol 15 ml. Conclusion: The preferred film-forming materials can be used for the preparation of compound corydalis painkiller.