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用频率为2450MHz功率密度为10mW/Cm~2(WBASAR约11.4W/kg)的微波(连续波)对置于微波暗室内的昆明种雄性小鼠急性全身照射1小时后,立即按常规方法断头,取脑,制成样品,然后用放射免疫测定法测量小鼠脑内乙酰胆碱(ACh)含量及胆碱乙酰转移酶(ChAT)活性。结果表明:照射组的ACh含量为11.6±1.4pmol/mg(脑鲜重),ChAT活性为45.4±8.7pmolACh/min.mg(脑鲜重);而对照组的分别为16.0±2.1pmol/mg和61.0±13.8pmolACh/min.mg。证明微波照射后可引起动物脑内ACh水平和ChAT活性下降,提示微波辐射对中枢胆碱能系统确有不利影响。
Kunming male mice placed in a microwave dark chamber were irradiated for 1 hour with a microwave (continuous wave) at a frequency of 2450 MHz at a power density of 10 mW / cm ~ 2 (WBASAR ~ 11.4 W / kg) The brain was taken out to make samples. The content of acetylcholine (ACh) and the activity of choline acetyltransferase (ChAT) in mouse brain were measured by radioimmunoassay. The results showed that the ACh content of irradiated group was 11.6 ± 1.4 pmol / mg (fresh weight of brain) and the activity of ChAT was 45.4 ± 8.7 pmolACh / min.mg (fresh weight of brain), while that of control group was 16.0 ± 2.1 pmol / mg And 61.0 ± 13.8 pmolACh / min.mg. Proved microwave irradiation can cause brain ACh levels and ChAT activity decreased, suggesting that microwave radiation on the central cholinergic system does have adverse effects.