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近年来特别在发展中国家很重视新的低剂量每月1针的女用避孕药。此类避孕针具有高效,不影响性生活,月经紊乱副反应比纯孕激素制剂少的优点。本文观察了妇女肌肉注射炔诺酮(NET)和炔雌醇甲醚(ME)的大结晶悬浮液,对排卵功能及月经出血类型的影响,并进行了药代动力学研究。研究包括10例健康妇女,年龄25.3±5.5岁,月经规则,周期24～35天,体重55.3±9.4kg,身高1.54±0.09m,产次1.1次。研究期间用屏障法避孕,每天记录月经卡。先随访1个周期作为对照周期,于月经第1～5天注射避孕针,每月1次,共2或3次。避孕针含 NET12mg 及 ME1.2mg,颗粒大小为125～177μm,悬浮于1ml 含0.1%吐温80
In recent years, especially in developing countries, great attention has been paid to the new low-dose female contraceptive with 1-pin per month. Such contraceptives with high efficiency, does not affect sexual life, side effects of menstrual disorders than progestin preparations less advantages. In this paper, we observed the effect of intramuscular injection of large crystalline suspensions of norethindrone (NET) and ethinylestradiol (ME) on ovulation and menstrual bleeding, and studied the pharmacokinetics. The study included 10 healthy women aged 25.3 ± 5.5 years with regular menstrual cycles of 24-35 days, weighing 55.3 ± 9.4 kg and height of 1.54 ± 0.09 m with a delivery frequency of 1.1. During the study with the barrier method of contraception, a daily record of menstruation card. First follow-up 1 cycle as the control cycle, in the menstrual 1 to 5 days injection of contraception, once a month, a total of 2 or 3 times. Contraceptives containing NET12mg and ME1.2mg, particle size of 125 ~ 177μm, suspended in 1ml with 0.1% Tween 80