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目的：探讨药物对肺纤维化早期的治疗作用。方法：采用石棉灌肺制成大鼠肺纤维化模型，在其早期给予刺五加和地塞米松体内实验治疗，动态观察肺泡炎阶段ＢＡＬＦ中ＩＬ－６水平和组织形态学改变。结果：刺五加组ＩＬ－６水平明显降低（Ｐ＜０．０１），激素组与对照组的ＩＬ－６水平降低不明显（Ｐ＞０．０５）。结论：刺五加组和激素组组织形态学改变均轻于非用药组对照。
Objective: To investigate the early therapeutic effect of drugs on pulmonary fibrosis. Methods: Pulmonary fibrosis model was induced by asbestosis in rat lungs. Experimental treatment of Acanthopanax senticosus and dexamethasone were performed in vivo. The level of IL-6 in BALF and histomorphology of alveolitis were observed dynamically. Results: The level of IL-6 in Acanthopanax senticosus group was significantly lower than that in Acanthopanax senticosus group (P <0.01), while the level of IL-6 in hormones group and control group was not significantly reduced (P> 0.05). Conclusion: The histological changes of Acanthopanax senticosus group and hormone group are lighter than that of non-medication group.