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目的：研究丹参提取物丹参酮亲水凝胶的释药性。方法：以卡波姆（Ｃａｒｂｏｍｅｒ） 、羟丙基甲基纤维素（ＨＰＭＣ） 和聚乙烯吡咯烷酮（ＰＶＰ） 为基质，制备丹参酮亲水凝胶，使用改良的Ｆｒａｎｚ 扩散池，进行体外释药试验。结果：发现凝胶剂中加入适量ＰＶＰ既可增加凝胶的粘结力，又可在一定范围内控制释药速率。结论：可供丹参酮外用贴剂研究提供帮助。
Objective: To study the drug release properties of Danshen extract hydrogel. Methods: The tanshinone hydrogel was prepared by using Carbomer, HPMC and PVP as matrix. The improved Franz diffusion cell was used for in vitro drug release test. RESULTS: It was found that addition of a suitable amount of PVP to the gelling agent can increase the binding force of the gel, and can also control the release rate within a certain range. Conclusion: It can be used for the study of tanshinone topical patch.