论文部分内容阅读
目的研究糖尿病脑病患者事件相关电位(ERP)的特征及早期评定患者有无认知功能障碍及严重程度的临床价值。方法对39例糖尿病脑病(DM&ICVD)患者、32例缺血性脑血管病(ICVD)患者及24例正常人进行事件相关电位检查及简易智能量表(MMSE)检测,将两组检测结果与正常对照组比较。结果 DM&ICVD组、ICVD组与正常组相比P300潜伏期显著延长,差异有统计学意义(P<0.01,P<0.05);MMSE评分DM&ICVD组较正常对照组降低,差异有统计学意义(P<0.01);DM&ICVD组P300潜伏期与MMSE评分呈负相关(r=-0.83,P<0.01)即P300潜伏期越长MMSE总分越低。结论 P300潜伏期的检测作为糖尿病脑病患者早期认知障碍的敏感指标,对于评定糖尿病脑病患者有无认知功能障碍及严重程度具有重要价值。
Objective To study the characteristics of incident-related potentials (ERP) in patients with diabetic encephalopathy and the clinical value of early assessment of patients with or without cognitive impairment and severity. Methods Event-related potentials and MMSE were measured in 39 patients with diabetic encephalopathy (DM & ICVD), 32 patients with ischemic cerebrovascular disease (ICVD) and 24 healthy controls. The results of two groups were compared with normal Comparison of the control group. Results The latency of P300 in DM & ICVD group and ICVD group was significantly longer than that in normal group (P <0.01, P <0.05). MMSE score in DM & ICVD group was lower than that in normal control group (P <0.01) ). The latency of P300 in DM & ICVD group was negatively correlated with MMSE score (r = -0.83, P <0.01), ie, the longer the latency of P300, the lower the MMSE score. Conclusion The detection of P300 latency as a sensitive indicator of early cognitive impairment in patients with diabetic encephalopathy is of great value in assessing the cognitive dysfunction and severity of patients with diabetic encephalopathy.