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目的比较宫颈电环切除术(LEEP)与射频消融术(RFA)治疗持续性宫颈上皮内瘤变Ⅰ级(CINⅠ)的治疗效果。方法将经阴道镜及活检病理证实为CINⅠ患者137例随机分为LEEP治疗组69例和RFA治疗组68例,对高危型HPV阳性患者术后均给予重组人干扰素α-2b凝胶治疗,比较两种治疗方式的临床疗效。结果 2组患者手术时间、治愈率、病变持续率及手术残留率比较差异均无统计学意义(P>0.05);LEEP治疗组术中出血量少于RFA治疗组(P<0.05),复发率低于RFA治疗组(P<0.05);2组术后并发症发生率比较差异无统计学意义(P>0.05)。结论 LEEP手术简便、廉价,患者无痛苦,术后恢复快,是目前治疗持续性CINⅠ安全有效的方法,只要掌握手术指征,规范手术步骤,可获得满意疗效,具有较好的临床推广价值。
Objective To compare the therapeutic effect of cervical electrocorticoid excision (LEEP) and radiofrequency ablation (RFA) in the treatment of persistent cervical intraepithelial neoplasia grade Ⅰ (CIN Ⅰ). Methods Seventy-three patients with CIN I who were confirmed by colposcopy and biopsy were randomly divided into LEEP treatment group (n = 69) and RFA treatment group (n = 68). High-risk HPV positive patients were treated with recombinant human interferon α-2b gel, Compare the clinical efficacy of the two treatment methods. Results There was no significant difference in operative time, cure rate, persistent disease rate and operative residual rate between the two groups (P> 0.05). LEEP treatment group had less intraoperative blood loss than RFA treatment group (P <0.05), and the recurrence rate (P <0.05). There was no significant difference in the incidence of postoperative complications between the two groups (P> 0.05). Conclusions LEEP is a simple and inexpensive procedure. It has no pain and quick recovery after operation. It is a safe and effective method for the treatment of persistent CIN Ⅰ. As long as the indications of the operation and the surgical procedures are met, the LEEP can obtain satisfactory curative effect and has good clinical promotion value.