论文部分内容阅读
本文应用NSAR诱发NIH小鼠前胃癌的动物模型,研究了中药R阻断癌变的预防作用及其对NK和SOD活性的影响。结果表明,中药R有显著的阻断癌变作用,且呈现明显的剂量效应关系.其中以每公斤体重4g的前期用药组效果较好,其抑制率为77.77％(P<0.01),提示该药主要作用于致癌过程的始发致突变阶段。中药R并可明显地提高NK和SOD活性,具有增强细胞免疫和解毒功能。是一种有苗头的化学预防药物,值得进一步开展人群干予试验和作用机制研究。
In this paper, the animal models of precancerous gastric cancer induced by NSAR in NSAR mice were used to study the preventive effect of traditional Chinese medicine R blocking canceration and its effect on the activity of NK and SOD. The results showed that traditional Chinese medicine R has a significant role in blocking canceration and showed a significant dose-effect relationship. Among them, the pre-treatment group with a body weight of 4 g per kilogram of body weight was better, with an inhibition rate of 77.77% (P<0.01), suggesting that the drug It mainly acts on the initial mutagenic phase of the carcinogenic process. Traditional Chinese medicine R can significantly increase the activity of NK and SOD, and it can enhance cellular immunity and detoxification. It is a kind of prophylactic chemical preventive medicine, and it is worthy to further carry out research on the population and the mechanism of action.