CGEN-25007治疗炎症性肠病表现良好效果

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2009年6月23日,Compugen公司宣布CGEN-25007治疗炎症性肠病的动物模型(IBD)显示出良好的治疗效果。CGEN-25007是一种Gp96多肽拮抗剂具有抗炎活性。最近的研究发现,CGEN-25007对三硝基苯磺酸诱导的结肠炎模型大鼠具有很好的保护作用,可增加大鼠的存活率,增加大鼠雄重,与阳性对照组皮质激素类药物作用相似,而阴性对照组大鼠显示出不可逆和致命性的衰竭综合征。研究证明了CGEN-25007具有治疗IBD及其他具有强烈炎症性的自身免疫疾病(如类风湿性关节)的潜在能力。
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