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目的 观察慢性阻塞性肺疾病(慢阻肺)患者在无氧阈时的运动风险.方法 选择2013年2月至2014年6月首都医科大学附属北京友谊医院确诊的慢阻肺稳定期患者62例,其中男56例,女6例,平均年龄(66±8)岁.使用功率自行车进行逐渐递增和症状自限性心肺运动试验,采用V-slope和通气当量的方法确定无氧阈,分析在无氧阈强度下的症状、心电图、经皮氧饱和度和呼吸储备.结果 53例(53/62,85％)患者可确定无氧阈,无氧阈占最大摄氧量的(68±10)％.受试者在无氧阈状态下,经皮氧饱和度在安全范同内(94±2)％,呼吸储备较高(平均48％),心电图未叶现心肌缺血改变,偶有房或室性期前收缩.结论 静息无明显缺氧的中蘑度慢阻肺患者可耐受较高强度的运动.“,”Objective To investigate the exercise-related risk at anaerobic threshold (AT) in patients with chronic obstructive pulmonary disease (COPD).Methods Sixty two patients [men 56,women 6,aged (66 ± 8) yr] with stable COPD in Beijing Friendship Hospital during 2013-2014,participated in this study.Incremental symptom-limited cardiopulmonary exercise test was performed on cycle ergometer.The AT was determined using the V-Slope technique and ventilatory equivalents for carbon dioxide and oxygen.Symptoms,10-lead electrocardiogram,oxygen saturation by pulse oximetry(SpO2) were monitored during exercise.Results The AT,detectable in 53 patients,occurred at (68 ± 10)％ of peak oxygen uptake(peak VO2).The SpO2 was in the safe range (94 ± 2) ％ and the respiratory reserve was relatively high at AT (i.e.48％).Conclusions High-intensity exercise training can be performed in patients with moderate-to-severe COPD without resting oxygen desaturation.