帕金森病(PD)是累及黑质和黑质纹状体通路的神经退行性疾病,其病因及发病机制至今未完全明确,目前研究资料认为,氧化应激和线粒体功能障碍在PD发病中起着关键作用。因此抗氧化治疗越来越受到重视。吡咯喹啉醌(PQQ)是20世纪70年代发现的一种氧化还原酶的新辅酶,其具有多种生物学功能,在医学领域有着广泛的应用前景。本文旨在就抗氧化剂在PD治疗中的新进展作一综述,同时分析PQQ的抗氧化作用在PD的防治中的优势。 Parkinson’s disease (PD) is a neurodegenerative disease involving the substantia nigra and nigrostriatal pathways. The etiology and pathogenesis of Parkinson’s disease (PD) have not yet been fully understood. Current research data suggest that oxidative stress and mitochondrial dysfunction play roles in the pathogenesis of PD The key role. Therefore, more and more attention to anti-oxidative therapy. Pyrroloquinoline quinone (PQQ) is a novel coenzyme of oxidoreductase discovered in 1970s. It has a variety of biological functions and has a wide range of applications in the medical field. This article aims to summarize the recent advances in antioxidants in the treatment of PD, and to analyze the advantages of PQQ in the prevention and treatment of PD.