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目的 探讨降纤酶对脑梗塞病人血浆蛋白 Ｃ、 Ｄ二聚体（ Ｄ Ｄｉｍ ｅｒ）的影响及治疗意义。方法 采用 Ａ Ｐ Ｔ Ｔ 法和 Ｅ Ｌ Ｉ Ｓ Ａ 法测定 ３０ 例脑梗塞病人和 ３０ 例正常对照者血浆蛋白 Ｃ 活性及 Ｄ二聚体含量。结果 急性脑梗塞病人血浆蛋白 Ｃ 活性及 Ｄ二聚体含量显著升高（ Ｐ＜ ０．０１），治疗后明显下降趋于正常（ Ｐ＜ ０．０１）。结论 降纤酶急性期应用可以发挥其降纤、溶纤作用，对凝血及纤溶机制产生一定影响。
Objective To investigate the effect of defibrase on plasma protein C and DDim er in patients with cerebral infarction and its therapeutic significance. Methods Plasma protein C activity and D-dimer content of 30 patients with cerebral infarction and 30 normal controls were measured by A T T method and E L I S A method. Results Plasma protein C activity and D-dimer level were significantly increased in patients with acute cerebral infarction (P <0.01), and the levels of D protein and protein decreased significantly after treatment (P <0.01). Conclusion The application of defibrase in acute phase can exert its anti-fibrinolytic and fibrinolytic effects, and have some effects on the coagulation and fibrinolytic mechanisms.