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目的：考察阿霉素壳寡糖-聚乳酸嫁接物胶团的缓释性能。方法以超声分散法制备嫁接物胶团；以阿霉素为模型药物，透析法制备载药胶团。进行载药胶团体外释放实验，考察壳寡糖-聚乳酸共聚物胶团的缓释性能。结果在壳寡糖-聚乳酸嫁接物中，聚乳酸分子量为5000的两种壳寡糖-聚乳酸嫁接物载药胶团体外释放缓释效果明显。结论壳寡糖-聚乳酸聚合物胶团具有显著的缓释特征。其中聚乳酸分子量为5000的壳寡糖-聚乳酸嫁接物，缓释效果更明显。“,”Objective Evaluate the ef iciency of delayed release in vitro of adriamycin chitosan-polylactic acid polymeric micel es.Methods Hypersound dispersion method to prepare the polymeric micel es. Adriamycin as a model drug was then incorporated into the micel es by dialysis. Evaluate the ef iciency of delayed release of adriamycin chitosan-polylactic acid polymeric micel es by in vitro investigation. Results The CSO-PLA micel es with 5000 molecule weight of PLA loading Adr displayed more sustained-release characteristic.Conclusion The micel es loading Adr displayed sustained-release characteristic in vitro. The CSO-PLA (PLA with molecule weight 5000) micel es loading Adr displayed significant sustained-release characteristic.